Article

Disrupted Hippocampal-Prefrontal Networks in a Rat Model of Fragile X Syndrome: A Study Linking Neural Dynamics to Autism-Like Behavioral Impairments

2024-10-16

Abstract excerpt

<h4>ABSTRACT</h4> Fragile X Syndrome (FXS) is associated with autism spectrum disorder (ASD) symptoms that are associated with cognitive, learning, and behavioral challenges. We investigated how known molecular disruptions in the Fmr1 knockout (FMR-KO) rat model of FXS negatively impact hippocampal-prefrontal cortex (H-PFC) neural network activity and consequent behavior. <h4>Methods</h4> FMR-KO and control rats...

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Literature Corpus work: bef7bfe7-c0e0-5afe-92c1-74dceea54b31
DOI: 10.1101/2024.10.15.617900

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