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Article

Cntnap2 Knockout Rats and Mice Exhibit Epileptiform Activity and Abnormal Sleep-Wake Physiology.

Sleep - 1 Jan 2017

Thomas Alexia M, Schwartz Michael D, Saxe Michael D, Kilduff Thomas S

Abstract excerpt

Study Objectives: Although recent innovations have enabled modification of the rat genome, it is unclear whether enhanced utility of rodents as human disease models will result. We compared electroencephalogram (EEG) and behavioral phenotypes of rats and mice with homozygous deletion of Cntnap2, a gene associated with cortical dysplasia-focal epilepsy (CDFE) and autism spectrum disorders (ASD). Methods: Male...

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PMID: 28364455
DOI: 10.1093/sleep/zsw026

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