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Early and transient increase in cortical pyramidal cell excitability and delayed alteration of evoked synaptic transmission and t-SNARE proteins content in the hippocampus and neocortex of neonatal and juvenile <i>STXBP1</i> heterozygous mice

2025-12-02

Abstract excerpt

<h4>Summary</h4> De novo mutations in the STXBP1 gene leads to the haploinsufficiency of Munc18.1 protein in patient, and represent one of the major causes of neurodevelopmental disorders including developmental epileptic and non-epileptic encephalopathies. Given the fundamental role of this protein in vesicular exocytosis, most electrophysiological studies have focused on the impact of this haploinsufficiency o...

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Literature Corpus work
9e1320f9-9b9e-561c-85e4-187df35aac5e
DOI
10.64898/2025.11.29.691294
Open publication

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Early and transient increase in cortical pyramidal cell excitability and delayed alteration of evoked synaptic transmission and t-SNARE proteins content in the hippocampus and neocortex of neonatal and juvenile <i>STXBP1</i> heterozygous miceDOI 10.64898/2025.11.29.691294
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