Article

Piezo1-mediated microtubule destabilisation promotes extracellular matrix rigidity induced smooth muscle cell hypertrophy

2023-04-12

Abstract excerpt

Decreased aortic compliance is a precursor to numerous cardiovascular diseases. Compliance is regulated by the rigidity of the aortic wall and the vascular smooth muscle cells (VSMCs) within it. Extracellular matrix stiffening, observed during ageing, reduces compliance and contributes to hypertension. In response to increased rigidity, VSMCs generate enhanced contractile forces that result in VSMC stiffening and...

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Literature Corpus work: f537dec8-7435-5c77-8ecc-185bf44b3315
DOI: 10.22541/au.168130121.10786946/v1

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