Article

A hydrogel-based model of aortic stiffness reveals that microtubules are novel regulators of smooth muscle cell hypertrophy

2022-11-29

Abstract excerpt

Decreased aortic compliance is a precursor to numerous cardiovascular diseases. Compliance is regulated by the stiffness of the aortic wall and the vascular smooth muscle cells (VSMCs) within it. During ageing, the extracellular matrix of the aortic wall stiffens, reducing compliance and leading to conditions such as hypertension. In response, VSMCs generate enhanced contractile forces and undergo hypertrophy, pro...

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Literature Corpus work: 999af1ea-03da-533d-a873-ac883986009c
DOI: 10.22541/au.166973991.19945400/v1

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