Article
Microskeletal stiffness promotes aortic aneurysm by sustaining pathological vascular smooth muscle cell mechanosensation via Piezo1.
Nature communications - 26 Jan 2022
Qian Weiyi, Hadi Tarik, Silvestro Michele, Ma Xiao, Rivera Cristobal F, Bajpai Apratim, Li Rui, Zhang Zijing, Qu Hengdong, Tellaoui Rayan Sleiman, Corsica Annanina, Zias Ariadne L, Garg Karan, Maldonado Thomas, Ramkhelawon Bhama, Chen Weiqiang
Abstract excerpt
Mechanical overload of the vascular wall is a pathological hallmark of life-threatening abdominal aortic aneurysms (AAA). However, how this mechanical stress resonates at the unicellular level of vascular smooth muscle cells (VSMC) is undefined. Here we show defective mechano-phenotype signatures of VSMC in AAA measured with ultrasound tweezers-based micromechanical system and single-cell RNA sequencing...
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