Article
Pressure and stiffness sensing together regulate vascular smooth muscle cell phenotype switching.
Science advances - 15 Apr 2022
Swiatlowska Pamela, Sit Brian, Feng Zhen, Marhuenda Emilie, Xanthis Ioannis, Zingaro Simona, Ward Matthew, Zhou Xinmiao, Xiao Qingzhong, Shanahan Cathy, Jones Gareth E, Yu Cheng-Han, Iskratsch Thomas
Abstract excerpt
Vascular smooth muscle cells (VSMCs) play a central role in the progression of atherosclerosis, where they switch from a contractile to a synthetic phenotype. Because of their role as risk factors for atherosclerosis, we sought here to systematically study the impact of matrix stiffness and (hemodynamic) pressure on VSMCs. Thereby, we find that pressure and stiffness individually affect the VSMC phenotype....
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