Article

Matrix stiffness and blood pressure together regulate vascular smooth muscle cell phenotype switching

2020-12-28

Abstract excerpt

Vascular smooth muscle cells (VSMCs) play a central role in the onset and progression of atherosclerosis. In pre-atherosclerotic lesions, VSMCs switch from a contractile to a synthetic phenotype and subsequently remodel the microenvironment, leading to further disease progression. Ageing and associated mechanical changes of the extracellular matrix as well as hypertension are major risk of atherosclerosis. Consequ...

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Literature Corpus work: 23ee3033-8191-5410-9c67-6b5d4ccd8967
DOI: 10.1101/2020.12.27.424498

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