Article

Reduction of Elevated Proton Leak Rejuvenates Mitochondria in the Aged Cardiomyocyte

2020-01-03

Abstract excerpt

Aging-associated diseases, including cardiac dysfunction, are increasingly common in the population. However, the mechanisms of physiologic aging in general, and cardiac aging in particular, remain poorly understood. Age-related heart impairment, especially diastolic dysfunction in HFpEF is lacking a clinically effective treatment. Using the model of naturally aging mice and rats, we show direct evidence of increa...

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Literature Corpus work: f52c3929-55b4-5d8c-9ae9-83fe5f2a801a
DOI: 10.1101/2020.01.02.893362

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