Article

Late-life restoration of mitochondrial function reverses cardiac dysfunction in old mice

2020-01-02

Abstract excerpt

Diastolic dysfunction is a prominent feature of cardiac aging in both mice and humans. We show here that 8-week treatment of old mice with the mitochondrial targeted peptide SS-31 (elamipretide) can substantially reverse this deficit. SS-31 normalized the increase in proton leak and reduced mitochondrial ROS in cardiomyocytes from old mice, accompanied by reduced protein oxidation and a shift towards a more reduce...

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Literature Corpus work: 8d1c27e0-b33a-542e-b759-5757643b64e3
DOI: 10.1101/2020.01.02.893008

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