Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification and characterization of Cardiac Glycosides as senolytic compounds

21 Oct 2019

Abstract excerpt

Compounds with specific cytotoxic activity in senescent cells, or senolytics, support the causal involvement of senescence in aging and offer therapeutic interventions. Here we report the identification of Cardiac Glycosides (CGs) as a family of compounds with senolytic activity. CGs, by targeting the Na+/K+ATPase pump, cause a disbalanced electrochemical gradient within the cell causing depolarization and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Advanced biosensing and bioanalysis techniques
Share to RNA Interference and Gene Delivery
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31636264
DOI: 10.1038/s41467-019-12888-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification and characterization of Cardiac Glycosides as senolytic compoundsPMID 31636264Read ↗

Apoptosis-resistance of senescent cells is an intrinsic barrier for senolysis induced by cardiac glycosidesSemantic proximity Read ↗

Cellular senescence and cardiovascular diseases: moving to the “heart” of the problemSemantic proximity Read ↗

Current senolytics: Mode of action, efficacy and limitations, and their future.Semantic proximity Read ↗

Therapeutic Potential of Senolytics in Cardiovascular DiseaseSemantic proximity Read ↗

Recent Advances in Senolysis for Age-Related DiseasesSemantic proximity Read ↗

Comparative Analysis of drugs that improve the Quality of Life and Life ExpectancySemantic proximity Read ↗

Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span.Semantic proximity Read ↗

Targeting Cellular Senescence for Age-Related Diseases: Path to Clinical TranslationSemantic proximity Read ↗

Senolytics: Targeting Senescent Cells for Age-Associated DiseasesSemantic proximity Read ↗

Senolytic and senomorphic interventions to defy senescence-associated mitochondrial dysfunction.Semantic proximity Read ↗

Procyanidin C1 is a natural agent with senolytic activity against aging and age-related diseasesSemantic proximity Read ↗

The flavonoid procyanidin C1 has senotherapeutic activity and increases lifespan in miceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.