Article

Estrogen Receptor Alpha Dynamics and Plasticity During Endocrine Resistance

2025-04-30

Abstract excerpt

<title>Abstract</title> <p>Background ER-α positive breast cancer, even though they respond to endocrine treatment, half of the patients acquire resistance and progress with metastasis despite ERα status. Spatio-temporal changes in ERα and their loss under treatment pressure have been reported in a subset of patients, which is a serious problem. Results We have demonstrated that in vitro-generated resistance is...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f527a85f-1d74-57a1-a7c1-d7be7798c7ab
DOI: 10.21203/rs.3.rs-6295413/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Estrogen Receptor Alpha Dynamics and Plasticity During Endocrine ResistanceDOI 10.21203/rs.3.rs-6295413/v1Read

Resistance to endocrine therapy in breast cancer: molecular mechanisms and future goalsSemantic proximity Read

Endocrine resistance in breast cancer--An overview and update.Semantic proximity Read

Novel insights into the molecular mechanisms of endocrine resistance in ERα positive breast cancerSemantic proximity Read

Endocrine therapy-specific lineage and partial epithelial-mesenchymal reprogramming defines divergent resistant cell-states in ER+ breast cancerSemantic proximity Read

Modulation of estrogen receptor alpha activity and expression during breast cancer progression.Semantic proximity Read

The natural L370F ERα Variant Confers Endocrine Resistance and Sensitivity to ATRA in Metastatic Breast Cancer CellsSemantic proximity Read

Endocrine-resistant breast cancer: underlying mechanisms and strategies for overcoming resistance.Semantic proximity Read

Estrogen Receptor Alpha Mutations, Truncations, Heterodimers, and Therapies.Semantic proximity Read

PML1-Mediated Feedforward Loop Through PI3K and MAPK Axes Drives Endocrine ResistanceSemantic proximity Read

Tamoxifen Response at Single Cell Resolution in Estrogen Receptor-Positive Primary Human Breast TumorsSemantic proximity Read

Estrogen Receptor Alpha and ESR1 Mutations in Breast Cancer.Semantic proximity Read

Decoding estrogen receptor and GPER biology: structural insights and therapeutic advances in ERα−positive breast cancerSemantic proximity Read