Article
Endocrine-resistant breast cancer: underlying mechanisms and strategies for overcoming resistance.
Breast cancer (Tokyo, Japan) - 1 Jan 2003
Kurebayashi Junichi
Abstract excerpt
Estrogen plays important roles in the development and progression of breast cancer. However, one-third of breast cancers fail to respond to endocrine therapy and most endocrine-responsive breast cancers subsequently become resistant to endocrine therapy. A tremendous effort has been made to elucidate the mechanisms responsible for the development of endocrine-resistance in breast cancer. Since the main target...
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