Article

PML1-Mediated Feedforward Loop Through PI3K and MAPK Axes Drives Endocrine Resistance

2025-05-16

Abstract excerpt

<h4>ABSTRACT</h4> Treatment of estrogen receptor-positive (ER+) breast cancer is significantly hindered by endocrine resistance. We identified PML1 as a key therapeutic entity that can be targeted to overcome resistance. Endocrine-resistant breast cancer cells share three key characteristics: elevated PML1 protein levels, enhanced activity of PI3K, MAPK, or both signaling pathways, and reduced ER activity. We dev...

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Literature Corpus work: 5f39a06c-628a-5fbe-b358-ba0d894a298e
DOI: 10.1101/2025.05.15.653365

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