Article

Tamoxifen Response at Single Cell Resolution in Estrogen Receptor-Positive Primary Human Breast Tumors

2023-04-03

Abstract excerpt

<h4>ABSTRACT</h4> In ER+/HER2- breast cancer, multiple measures of intra-tumor heterogeneity are associated with worse response to endocrine therapy. To investigate heterogeneity in response to treatment, we developed an operating room-to-laboratory pipeline for the collection of live human tumors and normal breast specimens immediately after surgical resection for processing into single-cell workflows for experi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cc44e257-34af-5a02-af17-c8e82d35c0bd
DOI: 10.1101/2023.04.01.535159

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Tamoxifen Response at Single Cell Resolution in Estrogen Receptor-Positive Primary Human Breast TumorsDOI 10.1101/2023.04.01.535159Read

Identification and characterization of a proliferative cell population in estrogen receptor-positive metastatic breast cancer through spatial and single-cell transcriptomicsSemantic proximity Read

A robust protocol for the systematic collection and expansion of cells from ER <sup>+</sup> breast cancer tumors and their matching tumor-adjacent tissuesSemantic proximity Read

A single-cell atlas of breast cancer cell lines to study tumour heterogeneity and drug responseSemantic proximity Read

Dissection of triple-negative breast cancer microenvironment and identification of potential therapeutic drugs using single-cell RNA sequencing analysisSemantic proximity Read

Molecular features of luminal breast cancer defined through spatial and single‐cell transcriptomicsSemantic proximity Read

A ‘one-two punch’ therapy strategy to target chemoresistance in estrogen receptor positive breast cancerSemantic proximity Read

Single‐cell transcriptional atlas of human breast cancers and model systemsSemantic proximity Read

Deciphering the gene regulatory circuitry governing chemoresistance in Triple-Negative Breast CancerSemantic proximity Read

Spatiotemporal organisation of residual disease in mouse and human BRCA1-deficient mammary tumours and breast cancerSemantic proximity Read

Distinct discrepancy in breast cancer organoids recapitulation among molecular subtypes revealed by single‐cell transcriptomes analysisSemantic proximity Read

The single-cell pathology landscape of breast cancer.Semantic proximity Read

A Multimodal Framework to Uncover Drug-Responsive Subpopulations in Triple-Negative Breast CancerSemantic proximity Read