Article

TRPV1 drugs alter core body temperature via central projections of primary afferent sensory neurons

2022-05-10

Abstract excerpt

TRPV1, a capsaicin- and heat-sensitive ion channel, is expressed by peripheral nociceptors and has been implicated in various inflammatory and neuropathic pain conditions. Although pharmacological modulation of TRPV1 has attracted therapeutic interest, their utility is limited because TRPV1 agonists and antagonists thus far examined show thermo-modulatory side effects in animal models and human clinical trials. Th...

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Literature Corpus work: f51912c7-9b09-545d-b3d2-1add499a816c
DOI: 10.1101/2022.05.09.491211

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