Article

A moduli-selective antibody inhibits the pain receptor TRPV1 in cynomolgus monkeys without adverse temperature dysregulation

2023-10-28

Abstract excerpt

The multimodal, transient receptor potential vanilloid-1 (TRPV1) ion-channel, mediates pain sensation, is implicated in thermal hyperalgesia, and considered a highly promising target for pain management. However, TRPV1 has many complicated and entangled functions or modalities, whereas several first-generation small molecule TRPV1 antagonists, e.g., AMG517, have shown analgesic effects in the clinic, many caused t...

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Literature Corpus work: 5bb25e60-358f-5f81-a976-920799c2e87c
DOI: 10.21203/rs.3.rs-3473970/v1

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