Article
Modulation of TRPV4 by diverse mechanisms.
The international journal of biochemistry & cell biology - 1 Sept 2016
Darby W G, Grace M S, Baratchi S, McIntyre P
Abstract excerpt
Transient receptor potential ion channels (TRP) are a superfamily of non-selective ion channels which are opened in response to a diverse range of stimuli. The TRP vanilloid 4 (TRPV4) ion channel is opened in response to heat, mechanical stimuli, hypo-osmolarity and arachidonic acid metabolites. However, recently TRPV4 has been identified as an ion channel that is modulated by, and opened by intracellular...
Topics
- Animals
- Gene Knockout Techniques
- Humans
- Mutation
- Protein Stability
- TRPV Cation Channels