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Article

Purinergic receptor P2Y1 regulates polymodal C-fiber thermal thresholds and sensory neuron phenotypic switching during peripheral inflammation.

Pain - 1 Feb 2012

Jankowski Michael P, Rau Kristofer K, Soneji Deepak J, Ekmann Katrina M, Anderson Collene E, Molliver Derek C, Koerber Richard H

Abstract excerpt

We have recently found that, following complete Freund's adjuvant (CFA)-induced inflammation, cutaneous polymodal nociceptors (CPM) lacking the transient receptor potential vanilloid 1 (TRPV1) are sensitized to heat stimuli. In order to determine possible mechanisms playing a role in this change, we examined gene expression in the L2/L3 sensory ganglia following CFA injection into the hairy hind paw skin and...

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Source

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Identifiers

PMID: 22137295
DOI: 10.1016/j.pain.2011.10.042
PMCID: PMC3264839

Genes

CPM
TRPV1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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