Article

Somatic Evolution Introduces Distinctive Changes in Proteome Composition in Cancer Types

2018-10-24

Abstract excerpt

On the proteome level, somatic evolution in cancer is asymmetric, with several amino acids being irreversibly lost and the others gained across cancer types. However, though the gains and losses of amino acids are consistent in multiple cancer types, their magnitudes and prevalences differ. Here, we analyzed data on circa three million amino acid substitutions in the Catalogue of Somatic Mutations in Cancer (COSMI...

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Literature Corpus work: f4f58d25-3dc9-57c7-9bbb-c764971005e9
DOI: 10.1101/451310

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