Article
The (non)malignancy of cancerous amino acidic substitutions.
Proteins - 15 Feb 2010
Talavera David, Taylor Martin S, Thornton Janet M
Abstract excerpt
The process of natural selection acts both on individual organisms within a population and on individual cells within an organism as they develop into cancer. In this work, we have taken a first step toward understanding the differences in selection pressures exerted on the human genome under these disparate circumstances. Focusing on single amino acid substitutions, we have found that cancer-related mutations...
Topics
- Amino Acid Substitution
- Binding Sites
- DNA Mutational Analysis
- Humans
- Mutation
- Neoplasms
- Polymorphism, Genetic
- Selection, Genetic