Article
Genome-wide mutational spectra analysis reveals significant cancer-specific heterogeneity.
Scientific reports - 27 Jul 2015
Tan Hua, Bao Jiguang, Zhou Xiaobo
Abstract excerpt
Cancer is widely recognized as a genetic disease in which somatic mutations are sequentially accumulated to drive tumor progression. Although genomic landscape studies are informative for individual cancer types, a comprehensive comparative study of tumorigenic mutations across cancer types based on integrative data sources is still a pressing need. We systematically analyzed ~10(6) non-synonymous mutations...
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