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Unique role for caspase-8 in the release of IL-1β and active caspase-1 from viable human monocytes during <i>Toxoplasma gondii</i> infection

2022-12-19

Abstract excerpt

Monocytes are among the first cells recruited to sites of infection and major producers of the potent proinflammatory cytokine IL-1β. We previously showed that IL-1β release during Toxoplasma gondii infection of primary human monocytes requires the NLRP3 inflammasome and caspase-1 activity but is independent of gasdermin D and pyroptosis. To investigate potential mechanisms of pyroptosis-independent release of IL...

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Literature Corpus work
f4efdf75-bb0c-5a95-952a-c55a147db928
DOI
10.1101/2022.12.18.520939
Open publication

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