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A Combination of Four Nuclear Targeted Effectors Protects <i>Toxoplasma</i> Against Interferon Gamma Driven Human Host Cell Death During Acute Infection

2023-12-25

Abstract excerpt

In both mice and humans, Type II interferon-gamma (IFNγ) is crucial for regulation of Toxoplasma gondii ( T. gondii ) infection, during acute or chronic phases. To thwart this defense, T. gondii secretes protein effectors hindering the host’s immune response. For example, T. gondii relies on the MYR translocon complex to deploy soluble dense granule effectors (GRAs) into the host cell cytosol or nucleus. Recen...

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Identifiers and source

Literature Corpus work
58daba47-8d95-551c-b0ab-8e4db6df26d6
DOI
10.1101/2023.12.24.573224
Open publication

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A Combination of Four Nuclear Targeted Effectors Protects <i>Toxoplasma</i> Against Interferon Gamma Driven Human Host Cell Death During Acute InfectionDOI 10.1101/2023.12.24.573224
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