Article

Caspase-14 recognizes and processes IL-1β in epithelial cells to drive anti-bacterial IgG production

2026-04-15

Abstract excerpt

Caspases-mediated processing of cytokines coordinates cell-autonomous defenses and induction of systemic inflammation 1 . While caspase-1 processes IL-1β and IL-18 2–5 , human caspase-4 processes IL-18 mainly in monocytes 6 . Caspase-14 is an exception, specializing in epidermal differentiation 7,8 , yet no cytokine target has been firmly established for caspase-14. Here, we report that recognition and IL-1β m...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f1a94396-aabe-54ae-9295-ee230fd3c291
DOI: 10.64898/2026.04.14.717951

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Caspase-14 recognizes and processes IL-1β in epithelial cells to drive anti-bacterial IgG productionDOI 10.64898/2026.04.14.717951Read

Inflammatory caspase regulation: maintaining balance between inflammation and cell death in health and diseaseSemantic proximity Read

Evolution of a Pyroptosis-Apoptosis crosstalk drives non-canonical inflammasome signallingSemantic proximity Read

Caspase‐11: The driving factor for noncanonical inflammasomesSemantic proximity Read

Manipulation of Interleukin-1β and Interleukin-18 Production by Yersinia pestis Effectors YopJ and YopM and Redundant Impact on VirulenceSemantic proximity Read

Human caspase-4 mediates noncanonical inflammasome activation against gram-negative bacterial pathogensSemantic proximity Read

Executioner caspases degrade essential mediators of pathogen-host interactions to inhibit growth of intracellular Listeria monocytogenesSemantic proximity Read

Caspases at the crossroads of immune-cell life and deathSemantic proximity Read

Unique role for caspase-8 in the release of IL-1β and active caspase-1 from viable human monocytes during <i>Toxoplasma gondii</i> infectionSemantic proximity Read

Early secretory antigen target of 6-kDa of Mycobacterium tuberculosis inhibits macrophage apoptosis and host defense via TLR2Semantic proximity Read

TNF licenses macrophages to undergo rapid caspase-1, -11, and -8-mediated cell death that restricts <i>Legionella pneumophila</i> infectionSemantic proximity Read

Transcriptome profiling of pathogen-specific CD4 T cells identifies T-cell-intrinsic caspase-1 as an important regulator of Th17 differentiationSemantic proximity Read

Caspase-4/11 exacerbates disease severity in SARS–CoV-2 infection by promoting inflammation and immunothrombosisSemantic proximity Read