Article

<i>pIGLET</i> : Safe harbor landing sites for reproducible and efficient transgenesis in zebrafish

2023-12-08

Abstract excerpt

<h4>ABSTRACT</h4> Standard methods for transgenesis in zebrafish depend on random transgene integration into the genome followed by resource-intensive screening and validation. Targeted vector integration into validated genomic loci using phiC31 integrase-based attP / attB recombination has transformed mouse and Drosophila transgenesis. However, while the phiC31 system functions in zebrafish, validated loci ca...

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Literature Corpus work: f4ee9417-a715-5c3a-9177-8f767942a3cc
DOI: 10.1101/2023.12.08.570868

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