Stable germline transgenesis using the <i>Minos</i> Tc1/ <i>mariner</i> element in the sea urchin, <i>Lytechinus pictus</i>

Abstract excerpt

Stable transgenesis is a transformative tool in model organism biology. While the sea urchin is one of the oldest animal models in cell and developmental biology, it has relied on transient manipulations of wild animals, and has lacked a strategy for stable transgenesis. Here we build on recent progress to develop a more genetically tractable sea urchin species, Lytechinus pictus , to establish a robust transgene...

Topics

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• CAR-T cell therapy research
• Disease Models, Animal
• DNA Mutational Analysis
• Genome
• Genomics
• Mutagenesis
• RNA Interference and Gene Delivery
• Virus-based gene therapy research

Identifiers and source

Literature Corpus work

e687a061-b908-5440-a8f5-67a7f713af7d

DOI

10.1101/2024.03.26.586777