Article

Structure of a lasso peptide bound ETB receptor provides insights into the mechanism of GPCR inverse agonism

2024-02-06

Abstract excerpt

<title>Abstract</title> <p>Lasso peptides exhibit a unique lariat-like knotted structure imparting exceptional stability and thus show promise as therapeutic agents that target cell-surface receptors. One such receptor is the human endothelin ET<sub>B</sub> receptor, which is implicated in challenging cancers with poor immunotherapy responsiveness. The <italic>Streptomyces</italic>-derived lasso peptide, RES-701-...

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Literature Corpus work: f4cf21c3-7693-5083-8a0d-467886473031
DOI: 10.21203/rs.3.rs-3824116/v1

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