EGF‐like and Other Disulfide‐rich Microdomains as Therapeutic Scaffolds

Abstract excerpt

Disulfide bonds typically introduce conformational constraints into peptides and proteins, conferring improved biopharmaceutical properties and greater therapeutic potential. In our opinion, disulfide-rich microdomains from proteins are potentially a rich and under-explored source of drug leads. A survey of the UniProt protein database shows that these domains are widely distributed throughout the plant and...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Biochemical and Structural Characterization
• Share to Peptidase Inhibition and Analysis
• Share to vaccines and immunoinformatics approaches