Article

Structural and functional determination of peptide versus small molecule ligand binding at the apelin receptor

2024-04-04

Abstract excerpt

<title>Abstract</title> <p>We describe a structural and functional study of the apelin receptor, a G protein-coupled receptor (GPCR) that binds two endogenous peptide ligands, apelin and Elabela/Toddler (ELA), to regulate cardiovascular development and function. Characterisation of novel, naturally occurring apelin receptor variants from the UK Genomics England 100,000 Genomes Project, in combination with AlphaFo...

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Literature Corpus work: 2f0b96ff-6866-5357-98e2-f8bb557d3912
DOI: 10.21203/rs.3.rs-3970502/v1

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