Article

Peptide molecular glues select between BET paralogues by exploiting allosteric sites and conformational dynamics

2025-09-24

Abstract excerpt

<h4>ABSTRACT</h4> Achieving selective target inhibition is critical for minimising drug side effects. This can be especially challenging when targeting individual members of protein families with high sequence similarity. A well-recognised example is the Bromodomain and Extraterminal domain (BET) family of proteins. Chemical inhibition of the acetyllysine (AcK)-binding bromodomains (BDs) of BET proteins has shown...

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Literature Corpus work: cfb19163-b2aa-57af-9d50-0ebd67884dc2
DOI: 10.1101/2025.09.24.678353

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