Article

Identification of a targetable ST2-expressing fibroblast subset driving Peutz-Jeghers syndrome polyposis

2023-11-30

Abstract excerpt

Peutz-Jeghers syndrome (PJS) is associated with early-onset and recurring gastrointestinal hamartomatous polyposis caused by hereditary inactivating mutations in the tumor suppressor gene LKB1 (STK11). Due to lack of efficient prophylactic therapies PJS patients require regular surgical interventions and have an increased risk of cancer. LKB1-deficient fibroblasts have been identified as drivers of polyposis, but...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d7fcb485-b97c-56ee-9675-4140e2656f11
DOI: 10.1101/2023.11.29.568817

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Identification of a targetable ST2-expressing fibroblast subset driving Peutz-Jeghers syndrome polyposisDOI 10.1101/2023.11.29.568817Read

Intestinal LKB1 loss drives a pre-malignant program along the serrated cancer pathwaySemantic proximity Read

Stromal Lkb1 deficiency leads to gastrointestinal tumorigenesis involving the IL-11-JAK/STAT3 pathway.Semantic proximity Read

IL-17 links the tumor suppressor LKB1 to gastrointestinal inflammation and polyposisSemantic proximity Read

Genetic and epigenetic profiling of a solitary Peutz-Jeghers colon polyp.Semantic proximity Read

LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposisSemantic proximity Read

Lung cancer as a predominant feature in a patient with Peutz-Jeghers syndrome: Case report.Semantic proximity Read

Extrinsic KRAS signaling shapes the pancreatic microenvironment through fibroblast reprogrammingSemantic proximity Read

Peutz-Jeghers syndrome without STK11 mutation may correlate with less severe clinical manifestations in Chinese patients.Semantic proximity Read

Single-cell transcriptomic profiling unravels the adenoma-initiation role of protein tyrosine kinases during colorectal tumorigenesisSemantic proximity Read

Distinct polyp recurrence timing and STK11 mutation status underlie clinical heterogeneity in pediatric Peutz-Jeghers syndrome.Semantic proximity Read

Cronkhite‒Canada syndrome as inflammatory hamartomatous polyposis: new evidence from whole transcriptome sequencing of colonic polypsSemantic proximity Read

One Mutation to Rule Them All: Mutant KRAS Controls Tumor Intrinsic and Microenvironment Signaling.Semantic proximity Read