Article
Stromal Lkb1 deficiency leads to gastrointestinal tumorigenesis involving the IL-11-JAK/STAT3 pathway.
The Journal of clinical investigation - 2 Jan 2018
Ollila Saara, Domènech-Moreno Eva, Laajanen Kaisa, Wong Iris Pl, Tripathi Sushil, Pentinmikko Nalle, Gao Yajing, Yan Yan, Niemelä Elina H, Wang Timothy C, Viollet Benoit, Leone Gustavo, Katajisto Pekka, Vaahtomeri Kari, Mäkelä Tomi P
Abstract excerpt
Germline mutations in the gene encoding tumor suppressor kinase LKB1 lead to gastrointestinal tumorigenesis in Peutz-Jeghers syndrome (PJS) patients and mouse models; however, the cell types and signaling pathways underlying tumor formation are unknown. Here, we demonstrated that mesenchymal progenitor- or stromal fibroblast-specific deletion of Lkb1 results in fully penetrant polyposis in mice. Lineage tracing...
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