Article

Ligand-independent EGFR oligomers do not rely on the active state asymmetric kinase dimer

2020-04-25

Abstract excerpt

The human Epidermal Growth Factor Receptor (EGFR/ERBB1) is a Receptor Tyrosine Kinase (RTK) that forms active oligomers in response to ligand. Much evidence indicates that EGFR/ERBB1 forms oligomers in the absence of ligand, but the structure and physiological role of these ligand-independent dimers remain unclear. We use fluorescence microscopy to measure the oligomer stability and FRET efficiency for homo- and h...

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Literature Corpus work: f4b488ca-1aeb-5d51-8b34-7c6439d65ca9
DOI: 10.1101/2020.04.24.056077

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