Article
Leukemia mutated proteins PHF6 and PHIP form a chromatin complex that represses acute myeloid leukemia stemness.
Genes & development - 1 Oct 2025
Pawar Aishwarya S, Somers Patrick, Alex Aleena, Grana Jason, Feist Victoria K, George Subin S, Jalnapurkar Sapana S, Antony Charles, Verner Roman, White-Brown Sanese K, Khera Mohit, Mendoza-Figueroa María Saraí, Liu Kathy Fange, Morrissette Jennifer J D, Gurbuxani Sandeep, Paralkar Vikram R
Abstract excerpt
Myeloid leukemias are heterogeneous cancers with diverse mutations, sometimes in genes with unclear roles and unknown functional partners. PHF6 and PHIP are two poorly understood chromatin-binding proteins recurrently mutated in acute myeloid leukemia (AML). PHF6 mutations are associated with poorer outcomes, whereas PHIP was recently identified as the most common selective mutation in Black patients with AML....
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