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Article

A conserved intratumoral regulatory T cell signature identifies 4-1BB as a pan-cancer target

3 Feb 2020

Abstract excerpt

Despite advancements in targeting the immune checkpoints program cell death protein 1 (PD-1), programmed death ligand 1 (PD-L1), and cytotoxic T lymphocyte-associated protein 4 (CTLA-4) for cancer immunotherapy, a large number of patients and cancer types remain unresponsive. Current immunotherapies focus on modulating an antitumor immune response by directly or indirectly expanding antitumor CD8 T cells. A...

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PMID: 32015231
DOI: 10.1172/jci128672

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