BAP1 and PTEN mutations shape the immunological landscape of clear cell renal cell carcinoma and reveal the intertumoral heterogeneity of T cell suppression: a proof-of-concept study.

doi:10.1007/s00262-022-03346-7

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Article

BAP1 and PTEN mutations shape the immunological landscape of clear cell renal cell carcinoma and reveal the intertumoral heterogeneity of T cell suppression: a proof-of-concept study.

Cancer immunology, immunotherapy : CII - 1 Jun 2023

Friedhoff Jana, Schneider Felix, Jurcic Christina, Endris Volker, Kirchner Martina, Sun Angela, Bolnavu Iulia, Pohl Laura, Teroerde Miriam, Kippenberger Maximilian, Schwab Constantin, Kaczorowski Adam, Zschäbitz Stefanie, Jäger Dirk, Hohenfellner Markus, Stenzinger Albrecht, Duensing Anette, Duensing Stefan

Abstract excerpt

Clear cell renal cell carcinoma (ccRCC) is an immunologically vulnerable tumor entity, and immune checkpoint inhibitors are now widely used to treat patients with advanced disease. Whether and to what extent immune responses in ccRCC are shaped by genetic alterations, however, is only beginning to emerge. In this proof-of-concept study, we performed a detailed correlative analysis of the mutational and...

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PMID: 36562826
DOI: 10.1007/s00262-022-03346-7
PMCID: PMC10198938

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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