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Article

4-1BB (CD137), an inducible costimulatory receptor, as a specific target for cancer therapy.

BMB reports - 1 Mar 2014

Vinay Dass S, Kwon Byoung S

Abstract excerpt

Although considerable progress has been made in understanding how tumors evade immune surveillance, measures to counter the same have not kept pace with the advances made in designing effective strategies. 4-1BB (CD137; TNFRS9), an activation-induced costimulatory molecule, is an important regulator of immune responses. Targeting 4-1BB or its natural ligand 4-1BB ligand (4-1BBL) has important implications in many...

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Identifiers

PMID: 24499671
DOI: 10.5483/bmbrep.2014.47.3.283
PMCID: PMC4163883

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4-1BB (CD137), an inducible costimulatory receptor, as a specific target for cancer therapy.PMID 24499671Read ↗

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