Article

The revised three-step detour pathway in dolichol biosynthesis is evolutionarily conserved in budding yeast

2026-04-16

Abstract excerpt

The identification of SRD5A3, a causative gene for congenital disorders of glycosylation (CDGs), together with its yeast ortholog DFG10 , established the prevailing model that dolichol is synthesized from polyprenol in a single step. Subsequently, a recent discovery of DHRSX in CDG patients revised this view and led to the proposal of a three-step detour pathway for dolichol biosynthesis. However, it remains uncl...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8c1bb6b2-a5f8-5b19-a479-c2c059a26fa9
DOI: 10.64898/2026.04.13.718314

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The revised three-step detour pathway in dolichol biosynthesis is evolutionarily conserved in budding yeastDOI 10.64898/2026.04.13.718314Read

SRD5A3 is required for converting polyprenol to dolichol and is mutated in a congenital glycosylation disorder.Semantic proximity Read

POLYPRENOL REDUCTASE2 Deficiency Is Lethal in Arabidopsis Due to Male Sterility.Semantic proximity Read

The N-glycosylation defect in Lec5 and Lec9 CHO cells is caused by absence of the DHRSX geneSemantic proximity Read

SRD5A3-CDG: Expanding the phenotype of a congenital disorder of glycosylation with emphasis on adult onset features.Semantic proximity Read

Genetic defects in dolichol metabolism.Semantic proximity Read

SRD5A3-CDG: a patient with a novel mutation.Semantic proximity Read

A case of fatal Type I congenital disorders of glycosylation (CDG I) associated with low dehydrodolichol diphosphate synthase (DHDDS) activity.Semantic proximity Read

A genome-wide CRISPR screen identifies the glycosylation enzyme DPM1 as a modifier of DPAGT1 deficiency and ER stressSemantic proximity Read

Repurposing the HMG-CoA Reductase Inhibitor Atorvastatin for SRD5A3-CDGSemantic proximity Read

Life with too much polyprenol: polyprenol reductase deficiency.Semantic proximity Read

Integrative modelling of the full-length human dehydrodolichyl diphosphate synthase using a hybrid computational and experimental approachSemantic proximity Read

A drug repurposing screen reveals dopamine signaling as a critical pathway underlying potential therapeutics for the rare disease DPAGT1-CDGSemantic proximity Read