Article
Expression cloning of a novel suppressor of the Lec15 and Lec35 glycosylation mutations of Chinese hamster ovary cells.
The Journal of biological chemistry - 14 Jun 1996
Ware F E, Lehrman M A
Abstract excerpt
Lec15 and Lec35 are recessive Chinese hamster ovary (CHO) cell glycosylation mutations characterized by inefficient synthesis and utilization, respectively, of mannose-P-dolichol (MPD). Consequently, Lec15 and Lec35 cells accumulate Man5GlcNAc2-P-P-dolichol and glucosaminyl-acylphosphatidylinosit...
Topics
- Amino Acid Sequence
- Animals
- Antigens, Polyomavirus Transforming
- Base Sequence
- CHO Cells
- Carbohydrate Sequence
- Clone Cells
- Cloning, Molecular
- Cricetinae
- DNA, Complementary
- Dolichol Monophosphate Mannose
- Endoplasmic Reticulum
- Genes, Recessive
- Glycosylation
- Glycosylphosphatidylinositols
- Mannosyltransferases
- Molecular Sequence Data
- Molecular Weight