Article

Repurposing the HMG-CoA Reductase Inhibitor Atorvastatin for SRD5A3-CDG

2026-01-20

Abstract excerpt

SRD5A3-CDG is a rare autosomal recessive congenital disorder of glycosylation characterized by multisystemic dysfunction, including neurological, psychomotor, cognitive, and visual impairments. Approximately 60 cases have been reported, with treatment limited to symptomatic management. SRD5A3 encodes a polyprenal reductase enzyme essential for synthesizing dolichol, a lipid carrier of the oligosaccharide precursor...

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Literature Corpus work: 694b2aef-52ed-594f-bafb-fec24cb189f5
DOI: 10.64898/2026.01.18.699766

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