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Article

Structure of the human heterotetrameric <i>cis</i> -prenyltransferase complex

2020-06-02

Abstract excerpt

The human cis -prenyltransferase (h cis -PT) is an enzymatic complex essential for protein N-glycosylation. Synthesizing the precursor of the glycosyl carrier dolichol-phosphate, we reveal here that h cis -PT exhibits a novel heterotetrameric assembly in solution, composed of two catalytic dehydrodolichyl diphosphate synthase (DHDDS) and two inactive Nogo-B receptor (NgBR) subunits. The 2.3 Å crystal structure...

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Identifiers and source

Literature Corpus work
6ce20666-73c6-5cfb-9494-fb984587dc2a
DOI
10.1101/2020.06.02.095570
Open publication

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Structure of the human heterotetrameric <i>cis</i> -prenyltransferase complexDOI 10.1101/2020.06.02.095570
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