Article

STING induces HOIP-mediated synthesis of M1 ubiquitin chains to stimulate NFκB signaling

2023-10-15

Abstract excerpt

STING activation by cyclic dinucleotides in mammals induces IRF3- and NFκB -mediated gene expression, and the lipidation of LC3B at Golgi-related membranes. While mechanisms of the IRF3 response are well understood, the mechanisms of NFκB activation mediated by STING remain unclear. We report that STING activation induces linear/M1-linked ubiquitin chain (M1-Ub) formation and recruitment of the LUBAC E3 ligase, HO...

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Identifiers and source

Literature Corpus work: f46eced0-a6cb-577f-8332-aaa5c13b6bfa
DOI: 10.1101/2023.10.14.562349

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