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Article

STING trafficking as a new dimension of immune signaling

13 Jan 2023

Abstract excerpt

The cGAS-STING pathway is an evolutionarily conserved immune signaling pathway critical for microbial defense. Unlike other innate immune pathways that largely rely on stationary cascades of signaling events, STING is highly mobile in the cell. STING is activated on the ER, but only signals after it arrives on the Golgi, and then it is quickly degraded by the lysosome. Each step of STING trafficking through the...

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PMID: 36705629
DOI: 10.1084/jem.20220990

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