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The Vesicular Glutamate Transporter Modulates Sex and Region-Specific Differences in Dopaminergic Neuron α-Synuclein Toxicity by Modifying Cytosolic Dopamine Levels

2026-01-21

Abstract excerpt

Parkinson’s disease disproportionately affects males; however, the cause of this sex difference is unknown. We found that expressing mutant α-synuclein A53T in Drosophila dopamine neurons recapitulates the sex differences observed in human Parkinson’s disease patients. Male flies exhibited greater age-related motor impairment and more severe dopamine neuron degeneration than females. Selective masculinization of...

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Literature Corpus work: f46b985d-4ec9-5c39-befa-76b90ec20633
DOI: 10.64898/2026.01.17.699798

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