Article
Ventral tegmental area dopamine neurons are resistant to human mutant alpha-synuclein overexpression.
Neurobiology of disease - 1 Sept 2006
Maingay Matthew, Romero-Ramos Marina, Carta Manolo, Kirik Deniz
Abstract excerpt
Parkinson's disease (PD) is characterized by the formation of intracytoplasmic inclusions, which contain alpha-synuclein (alpha-syn) protein. While most profound neurodegeneration is seen in the dopamine (DA) synthesizing neurons located in the ventral midbrain, it is unclear why some DA cell gro...
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