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Article

Neuronal expression of familial Parkinson's disease A53T α-synuclein causes early motor impairment, reduced anxiety and potential sleep disturbances in mice.

Journal of Parkinson's disease - 1 Jan 2013

Rothman Sarah M, Griffioen Kathleen J, Vranis Neil, Ladenheim Bruce, Cong Wei-na, Cadet Jean-Lud, Haran Jamie, Martin Bronwen, Mattson Mark P

Abstract excerpt

BACKGROUND: Mutations in the human α-synuclein gene lead to early-onset Parkinson's disease (PD); however, phenotypes of α-synuclein mutant mice vary depending upon the promoter driving transgene expression. OBJECTIVE: The goal of this study was to characterize behavior and neurochemical alterations in mice expressing mutant (A53T) human α-synuclein, controlled by a neuron-specific Thy-1 promoter. Our data...

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PMID: 23938351
DOI: 10.3233/JPD-120130

Genes

SNCA

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