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Article

The novel adaptive rotating beam test unmasks sensorimotor impairments in a transgenic mouse model of Parkinson's disease.

Behavioural brain research - 1 May 2016

Gerstenberger Julia, Bauer Anne, Helmschrodt Christin, Richter Angelika, Richter Franziska

Abstract excerpt

Development of disease modifying therapeutics for Parkinson's disease (PD), the second most common neurodegenerative disorder, relies on availability of animal models which recapitulate the disease hallmarks. Only few transgenic mouse models, which mimic overexpression of alpha-synuclein, show dopamine loss, behavioral impairments and protein aggregation. Mice overexpressing human wildtype alpha-synuclein under...

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PMID: 26880341
DOI: 10.1016/j.bbr.2016.02.017

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