Article

The synovial lining macrophage layer develops in the first weeks of life in a CSF1- and TGFβ-dependent but monocyte-independent process

2025-05-26

Abstract excerpt

<h4>Summary</h4> Synovial joints harbor a protective lining layer, consisting of fibroblasts and macrophages, which form an epithelial-like barrier. In inflamed joints, lining macrophages regulate both early inflammatory cell influx and resolution. Despite these critical functions, it is currently unknown at what stage during development the synovial macrophage lining is established, and which signals drive this...

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Literature Corpus work: 30458c33-a0b1-568a-b289-d1c10a09a7a7
DOI: 10.1101/2025.05.21.655269

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