Article

Age-associated spontaneous activation of BMP signaling inhibits the canonical Wnt pathway through ICAT to promote osteoarthritis

2024-10-06

Abstract excerpt

Osteoarthritis (OA) is a highly prevalent and debilitating musculoskeletal disorder that affects billions of aging individuals worldwide, causing chronic pain, impaired mobility, and a substantial decline in quality of life, yet effective disease-modifying therapies remain unavailable. Moreover, existing experimental models, however, inadequately capture the complex, age-related factors that contribute to OA patho...

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Literature Corpus work: 30723159-5401-5d9f-a645-217a170fc4ff
DOI: 10.1101/2024.10.02.616036

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